FBI agent Gabriel Dean rushes into action to protect his pregnant wife, homicide detective Jane Rizzoli, when she is taken hostage along with others at the hospital by Nicholas Tennant, a black-ops agent in possession of high-level government secrets.
During a state funeral for a former First Lady at a New York City cathedral, armed men disguised as monks seize the church and dozens of hostages, and NYPD officer Michael Bennett takes on the dangerous role of lead negotiator in the standoff.