A mathematically gifted seven-year-old girl finds herself in the middle of a custody battle between her uncle and grandmother who have differing opinions on how she should be raised.

As ex-supervillain Gru is adjusting to family life and earning an honest living, the Anti-Villain League seek his help in stopping a new super criminal.

As the tenth season kicks off, Jay's slated to be grand marshal in a Fourth of July parade, prompting the Pritchett-Dunphy-Tuckers to set off a few too many fireworks. Phil stumbles into a new career opportunity, while Claire grapples with her potentially changing role in the family. Meanwhile, Gloria obsesses over Manny's relationship and Joe's extracurricular activities. The extended family deals with death, but they also evolve, with more laughs...

Larry Daley is a divorced father who can't seem to keep a job for more than a week. He applies for a job at the Museum of Natural History and is assigned as a night guard. However, a seemingly easy job turns out to be an adventure when he finds that an ancient curse has caused the "inhabitants" of the museum to come to life.