After his premature daughter is born and placed on a ventilator, Hurricane Katrina strikes New Orleans and the father must find a way to keep his child alive while waiting for someone to rescue them from a dark hospital.

When David Dunn, a security guard with superhuman gifts, is sent to a mental institution, he must contend with his archenemy Mr. Glass and Kevin Wendell Crumb, also known as "The Horde" for his multiple personalities, along with a psychiatrist trying to prove they do not have superhuman abilities.