In all the years she has watched the wolves in the woods behind her house, Grace has been particularly drawn to an unusual yellow-eyed wolf, unaware he turns into a human for a short time each year, but when the two find one another in human form, they vow to do whatever it takes to stay together.

After he is transformed into a 155-pound female breast, college professor David Kepesh struggles to rationalize his condition by proving he is insane.

As Grace hides the vast depth of her love for Sam from her parents and Sam struggles to release his werewolf past and claim a human future, a new wolf named Cole wins Isabel's heart but his own past threatens to destroy the whole pack.